Role of oxygen radicals in tumor promotion

摘要: Tumor promoters provoke the elaboration of oxygen radicals by direct chemical generation and through indirect activation or alteration cellular sources including membrane oxidases, peroxisomes, electron transport chains in mitochondria endoplasmic reticulum. Although measurement amplified radical production response to tumor target tissues remains problematic, studies with scavengers reactive species demonstrate inhibition biochemical biological sequelae promoter exposure provide strong presumptive evidence for involvement this late stage carcinogenesis. The critical macromolecular targets these remain undefined; however, they may include lipids, DNA, DNA repair systems, other enzymes.