Validation of a single-sample urinary C-peptide creatinine ratio as a reproducible alternative to serum C-peptide in patients with Type 2 diabetes.

摘要: Diabet. Med. 29, 90–93 (2012) Abstract Aims  Serum C-peptide can be used in Type 2 diabetes as a measure of endogenous insulin secretion, but practicalities collection limit its routine clinical use. Urine creatinine ratio is non-invasive alternative that stable for at least 3 days room temperature boric acid preservative. We aimed to assess the utility urine individuals with an serum C-peptide. Methods  assessed, 77 diabetes, reproducibility of, and correlations between, fasting postprandial C-peptide, impact renal impairment (estimated glomerular filtration rate < 60 ml min−1 1.73 m−2) on these correlations. Results  was reproducible [fasting coefficient variation mean (95% CI): 28 (21–35)% vs. 38 (26–59)% 2-h post-meal 26 (18–33)% 27 (20–34)%. 2 h correlated stimulated both value (r = 0.64, P < 0.001) area under curve (r = 0.63, P < 0.001). The association seen similar patients without moderate (P = 0.6). Conclusions  In single stable, well following meal stimulation, even if there impairment. therefore has potential use practice assessment diabetes.