Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes.

摘要: Diabet. Med. 28, 1034–1038 (2011) Abstract Aims  Serum C-peptide measurement can assist clinical management of diabetes, but practicalities collection limit widespread use. Urine creatinine ratio may be a non-invasive practical alternative. The stability in urine allows outpatient or community testing. We aimed to assess how compared with serum during mixed-meal tolerance test individuals late-onset, insulin-treated diabetes. Methods  correlated the gold standard stimulated fasting and (mixed-meal test, home meal largest meal) 51 subjects diabetes (diagnosis after age 30 years, median age 66 years, at diagnosis 54, 42 Type 2 estimated glomerular filtration rate > 60 ml min−1 1.73 m−2). Results  Ninety-minute is test-stimulated (r = 0.82), breakfast (r = 0.73) (r = 0.71). A (largest cut-off 0.3 nmol/mmol had 100% sensitivity 96% specificity (area under receiver operating characteristic curve = 0.99) identifying without clinically significant endogenous insulin secretion < 0.2 nmol/l). In detecting proposed threshold for requirement (stimulated < 0.6 nmol/l), 0.6 nmol/mmol 92%. Conclusion  patients diagnosed 30 years, well provide alternative measure detect deficiency use routine practice.