Characteristics of Endotoxin Altering Fractions Derived from Normal Human Serum

摘要: Summary Alcoholic fractionation of normal human defibrinated plasma by Cohn9s method 10 resulted in two fractions capable altering bacterial endotoxins. Incubation endotoxin the first, Fraction IV 1 , a marked reduction ability specific antiserum to precipitate endotoxin. In addition, capacity lipopolysaccharide elicit pyrogenic response rabbits was abolished. A second fraction, III 0 as isolated, generally incapable such effects unless it activated several procedures. All other did not affect these properties Alteration lethal activity evident after incubation but reduced exposure . The characteristics reactions are recorded.