Prevalence of Hepatitis E Virus Antibodies Among Blood Donors: A Systematic Review and Meta-Analysis

摘要: Context: Hepatitis E virus (HEV) is well-known to be transmitted by the fecal-oral route. In addition, several studies in Europe and Asia had reported potential HEV transmission associated with blood transfusion, but this route still uncertain. Objective: The aim of study was estimate anti-HEV IgG seroprevalence among donors around world using Bayesian-based methods. Evidence Acquisition: A systematic review performed PubMed/Medline, Scopus, Web Science Cochrane Library databases terms “prevalence”, “hepatitis E” “blood donors”. Studies a timeframe from inception March 2016, Roman characters, that outcomes interest such as prevalence antibodies were included. estimation (presented event rate 95% confidence intervals, CI) random effect model Comprehensive Meta-Analysis software, version 2. Pairwise meta-analyses chi-square tests used assess significant differences between different sexes ages. Results Conclusions: Of retrieved studies, 71 met inclusion criteria, comprising total 113 316 donors. statistically males over 40 years old (P < 0.05). overall 0.058 (CI 95%: 0.049 - 0.068). Subgrouping region, estimates higher for Middle East, respectively: 0.113 0.040 0.278) 0.112 0.081 0.152). Europe, Africa, Oceania America an estimated 0.014and 0.088. relevant found worldwide, especially East years. This reinforces view parenteral infection needs further investigated possibly screened transfused blood.