Vitamin E intake and the lung cancer risk among female nonsmokers: A report from the Shanghai Women's Health Study

摘要: Vitamin E includes several tocopherol isoforms which may reduce lung cancer risk, but past studies evaluating the association between vitamin intake and risk were inconsistent. We prospectively investigated associations from diet supplements with among 72,829 Chinese female nonsmokers aged 40-70 years participating in Shanghai Women’s Health Study (SWHS). Dietary supplement exposure was assessed by a validated food-frequency questionnaire at baseline, also reassessed for change during follow-up. Cox proportional hazards models time-dependent covariates used to calculate multivariate-adjusted hazard ratios (HRs) 95% confidence interval (CIs) cancer. After 12.02 of follow-up, 481 women diagnosed Total dietary inversely associated meeting guidelines adequate (AI) (14 mg/day or more: HR: 0.78; CI 0.60-0.99; compared category less than AI). The protective restricted exposed side-stream smoke home workplace (HR=0.53 (0.29-0.97), p-trend = 0.04). In contrast, use increased (HR: 1.33; 1.01-1.73), more so adenocarcinoma 1.79; 1.23-2.60). summary, non-smokers, however increase requires further investigation.