Strategies for interfacing with the trigeminal nerves in rodents for bioelectric medicine

摘要: Abstract Background Bioelectric medicine seeks to modulate neural activity via targeted electrical stimulation treat disease. Recent clinical evidence supports trigeminal nerve as a bioelectric treatment for several neurological disorders; however, the mechanisms of and potential side effects remain largely unknown. The goal this study is optimize methodology reproducibility interface implantation mechanistic studies in rodents. New method(s) This article describes single incision surgical approach infraorbital rats mice supraorbital studies. also presents use cortical evoked potentials electromyography methods demonstrating effective engagement between implanted electrode target nerve. Comparison with existing A number approaches exist, many which are technically difficult. simple, standardized mice, well integral future Conclusion can be easily accessed from dorsal on bridge nose that avoids major anatomical structures such facial accessible incision, but not due size. Successful interfacing infra- nerves using described demonstrated by recording electromyography.