Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration.
作者： S V Goverdhan , S Ennis , S R Hannan , K C Madhusudhana , A J Cree
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摘要: Background/aims: To determine whether four expression-related cytokine polymorphisms are associated with age-related macular degeneration (AMD). Methods: DNA from 478 cases AMD and 555 normal controls was genotyped for the pro-inflammatory IL1beta -511C/T, IL6 -174C/G, IL8 -251A/T anti-inflammatory IL10 -1082G/A using 5' nuclease TaqMan(R) assay allelic discrimination. Associations were analysed frequencies. Results: The -251A allele of promoter gene polymorphism more prevalent in patients than (p = 0.037, OR 1.21, 95% CI 1.01 to 1.44). Adjusting age, sex, body mass index (BMI), current smoking past status did not alter association significantly (corrected p value 0.043, 1.23, 1.0 1.50). Conclusion: homozygous -251AA genotype is an important risk factor AMD. This may have implications future therapy biological agents that could target this cytokine.
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