PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD
作者： Yandi Syukri , Laryssa Fernenda , Fissy Rizki Utami , Isna Qiftayati , Aris Perdana Kusuma
DOI: 10.14499/INDONESIANJPHARM26ISS2PP71
关键词:
摘要: Glimepiride is an oral antidiabetic drugs which practically insoluble in water. The formation of β-cyclodextrin inclusion complex was able to increase the solubility glimepiride. This study aim prepare, characterize and formulation tablets order meet requirement Pharmacopeia. were prepared a molar ratio 1:1 1:2 by freeze drying method, afterthat characterized include FTIR spectroscopy scanning electro microscope (SEM). Further, it formulated into direct compression technique using primogel crospovidone as superdisintegrants. evaluated weight uniformity, hardness, friability, disintegration, dissolution. dissolution studies performed USP II apparatus. result SEM provided evidence complexes after utilizing freeze-drying methods. tablet evaluation containing glimepiride-β cyclodextrin with cropovidone disintegrant showed that increased concentration will disintegration time tablets. All formulas requirements Pharmacopoeia. glimepiride–β successfully used for enhancing glimepiride Keywords: Glimepirid, β -cyclodextrin, primogel,
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