Neuroprotection of microRNA in neurological disorders (Review)

摘要: MicroRNAs (miRNAs) are small, endogenous, non-coding RNA molecules that function as post-transcriptional regulators of gene expression by imperfect base-pairing with the 3'-untranslated regions their target mRNAs. Altered numerous miRNAs has been shown to be extensively involved in pathogenesis various diseases and cancers. Additionally, specific nervous system indicated critical for occurrence development neurological diseases. Increasing evidence particular proteins significant disease pathogenesis. Therefore, miRNA-mediated regulation may important a novel biomarker tool clinical therapy. In present study, significance is reviewed number disorders possibility use therapeutic interventions evaluated.