The EGF domain: requirements for binding to receptors of the ErbB family.
作者： Everardus J.J. Van Zoelen , Catelijne Stortelers , Anne E.G. Lenferink , Monique L.M. Van De Poll
DOI: 10.1016/S0083-6729(00)59005-0
关键词:
摘要: Epidermal growth factor (EGF) has been the prototype growth-stimulating peptide for many years. It a characteristic structure with three disulfide bridges, which is essential its activity. However, other proteins, including both factors and proteins unrelated functions, have similar EGF-like domains. This indicates that besides conformation provided by domain, specific amino acids are required to provide specificity in protein functioning. Currently, more than 10 different an domain characterized all exert their action binding four members of erbB family receptors. In this review, studies described on structure-function relationship these molecules attempt analyze individual determine family.
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