Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage

摘要: Neutrophil gelatinase-associated lipocalin (Ngal, 24p3, SIP24, 2, or siderocalin) was originally purified from neutrophils, but with unknown function. Recently, it identified that Ngal activates nephron formation in the embryonic kidney, is rapidly and massively induced renal failure possesses kidney-protective activity. We would like to propose blood, urine, kidney levels are real-time indicators of active damage, rather than one many markers functional number (as Forest Fire Theory). a novel iron-carrier protein exerting pleiotropic actions including upregulation epithelial marker E-cadherin expression, opening an exciting field cell biology.