Functioning of the mitochondrial ATP-dependent potassium channel in rats varying in their resistance to hypoxia. Involvement of the channel in the process of animal’s adaptation to hypoxia
作者： Galina D. Mironova , Maria I. Shigaeva , Elena N. Gritsenko , Svetlana V. Murzaeva , Olga S. Gorbacheva
DOI: 10.1007/S10863-010-9316-5
关键词:
摘要: The mechanism of tissue protection from ischemic damage by activation the mitochondrial ATP-dependent K+ channel (mitoKATP) remains unexplored. In this work, we have measured, using various approaches, transport in rats that differed their resistance to hypoxia. was found be faster hypoxia-resistant as compared hypoxia-sensitive animals. Adaptation animals intermittent normobaric hypoxia increased rate transport. At same time, intramitochondrial concentration higher than resistant and adapted This indicates adaptation stimulates not only influx potassium into mitochondria, but also K+/H+ exchange. When mitoKATP blocked, H2O2 production significantly natural flavonoid-containing adaptogen Extralife, which has an evident antihypoxic effect, vitro vivo tolerance acute 5-fold. involvement cell is discussed.
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sci-hub.se 参考文章(31)
Mironova Gd, Baranova Ov, Skarga Yy, Negoda Ae, Inhibition of 2,4-dinitrophenol-induced potassium efflux by adenine nucleotides in mitochondria. Biochemistry. ,vol. 65, pp. 218- ,(2000)
Martin Jabůrek, Vladimir Yarov-Yarovoy, Petr Paucek, Keith D. Garlid, State-dependent Inhibition of the Mitochondrial KATP Channel by Glyburide and 5-Hydroxydecanoate Journal of Biological Chemistry. ,vol. 273, pp. 13578- 13582 ,(1998) , 10.1016/S0021-9258(19)57796-1
R. Portenhauser, G. Schäfer, R. Trolp, Inhibition of mitochondrial metabolism by the diabetogenic thiadiazine diazoxide. II. Interaction with energy conservation and ion transport. Biochemical Pharmacology. ,vol. 20, pp. 2623- 2632 ,(1971) , 10.1016/0006-2952(71)90171-7
L. D. Lukyanova, E. L. Germanova, R. A. Kopaladze, Development of resistance of an organism under various conditions of hypoxic preconditioning: role of the hypoxic period and reoxygenation. Bulletin of Experimental Biology and Medicine. ,vol. 147, pp. 400- 404 ,(2009) , 10.1007/S10517-009-0529-8
Sergey S. Korshunov, Vladimir P. Skulachev, Anatoly A. Starkov, High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria FEBS Letters. ,vol. 416, pp. 15- 18 ,(1997) , 10.1016/S0014-5793(97)01159-9
S.M. Grigoriev, Yu.Yu. Skarga, G.D. Mironova, B.S. Marinov, Regulation of mitochondrial KATP channel by redox agents. Biochimica et Biophysica Acta. ,vol. 1410, pp. 91- 96 ,(1999) , 10.1016/S0005-2728(98)00179-0
Chang-Her Tsai, Sheng-Fang Su, Tsai-Fwu Chou, Tsung-Ming Lee, Differential Effects of Sarcolemmal and Mitochondrial KATP Channels Activated by 17β-Estradiol on Reperfusion Arrhythmias and Infarct Sizes in Canine Hearts Journal of Pharmacology and Experimental Therapeutics. ,vol. 301, pp. 234- 240 ,(2002) , 10.1124/JPET.301.1.234
Irina B. Krylova, Evgeniya V. Kachaeva, Olga M. Rodionova, Alexander E. Negoda, Nataliya R. Evdokimova, Maria I. Balina, Nikolay S. Sapronov, Galina D. Mironova, The cardioprotective effect of uridine and uridine-5'-monophosphate: the role of the mitochondrial ATP-dependent potassium channel. Experimental Gerontology. ,vol. 41, pp. 697- 703 ,(2006) , 10.1016/J.EXGER.2006.03.005
K. N. Belosludtsev, N. V. Belosludtseva, G. D. Mironova, Possible Mechanism for Formation and Regulation of the Palmitate-Induced Cyclosporin A-Insensitive Mitochondrial Pore Biochemistry. ,vol. 70, pp. 815- 821 ,(2005) , 10.1007/S10541-005-0189-X
Toshiaki Sato, Brian O’Rourke, Eduardo Marbán, Modulation of Mitochondrial ATP-Dependent K+ Channels by Protein Kinase C Circulation Research. ,vol. 83, pp. 110- 114 ,(1998) , 10.1161/01.RES.83.1.110