Prefrontal GABA concentration changes in women-Influence of menstrual cycle phase, hormonal contraceptive use, and correlation with premenstrual symptoms.

摘要: Prefrontal regions are involved in processing emotional stimuli and a topic of interest clinical neurological research. Although sex steroids potent neuromodulators, the influence menstrual cycle phase hormonal contraceptive use is rarely taken into account neuroimaging studies. Our purpose was to evaluate changes gamma-aminobutyric acid (GABA) women, as measured by magnetic resonance spectroscopy (MRS), with phases contraceptives, assess correlations premenstrual symptoms.Three MRI sessions per were obtained natural group, two contraceptives group. In addition an anatomical scan, single voxel MRS prefrontal area performed. After quality control, 10 women 21 taking included for analysis. Peripheral blood samples determine endogenous hormone concentrations. Subjects asked complete daily rating severity problems questionnaire, quantify symptoms. we found significant increase GABA concentration at time ovulation. Conversely, no differences between pill pill-free phase. concentrations did not significantly correlate levels, nor results indicate that spectroscopically higher during ovulation cycle. We suggest studies should take this variability.