GABA quantitation using MEGA-PRESS: Regional and hemispheric differences.
作者： Monika Grewal , Aroma Dabas , Sumiti Saharan , Peter B. Barker , Richard A.E. Edden
DOI: 10.1002/JMRI.25324
关键词:
摘要: PURPOSE To measure in vivo brain gamma-aminobutyric acid (GABA) concentrations, and assess regional hemispheric differences, using MR spectroscopy (1 H-MRS). MATERIALS AND METHODS GABA concentrations were measured bilaterally the frontal cortex (FC), parietal (PC), occipital (OC) of 21 healthy young subjects (age range 20-29 years) 3 Tesla Philips scanner. A univariate general linear model analysis was carried out to effect region hemisphere as well their interaction on while controlling for sex gray matter differences. RESULTS Results indicated a significant dependence levels [F(2,89) = 11.725, P < 0.001, ηp2 = .209] with lower FC compared both PC (P < 0.001) OC regions. There no differences [F(1,89) = .172; P = 0.679; ηp2 = .002]. CONCLUSION This study reports FC, PC, regions adults. distribution exhibits symmetry, but varies across regions; are than those OC. J. Magn. Reson. Imaging 2016;44:1619-1623.
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