Strength of resting state functional connectivity and local GABA concentrations predict oral reading of real and pseudo-words.

摘要: Reading is a learned activity that engages multiple cognitive systems. In cohort of typical and struggling adult readers we show evidence successful oral reading real words related to gamma-amino-butyric acid (GABA) concentration in the higher-order language system, whereas unfamiliar pseudo-words not GABA this system. We also demonstrate capability resting state functional connectivity (rsFC) combined with measures predict single word compared pseudo-word performance. Results strength rsFC between left fusiform gyrus (L-FG) systems predicts behavior words, irrespective local GABA. On other hand, pseudo-words, which require grapheme-to-phoneme conversion, are predicted by connection L-FG This suggests may have multi-functional role: lexical processing pseudo-words. Additionally, L-FG, pre-motor, putamen areas positively both suggesting text be converted into phoneme sequence for speech initiation production regardless whether stimulus or pseudo-word. summary, from neuroscience perspective, that: (i) strong higher order visual, language, pre-motor can differentiate efficient (ii) measures, along rsFC, help further neural pathways previously versus