Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients.

摘要: Purpose To explore the functional connection strength (FCS) changes of brain networks in diabetic retinopathy (DR) patients and uncover underlying mechanism. Methods Materials Twenty-one with DR 21 age- sex-matched healthy controls were enrolled from August 2012 to September 2014. Subjects scanned using 3T MR blood-oxygen-level dependent (BOLD) 3-dimension fast spoiled gradient echo (3D-FSPGR) sequences. data was analyzed via preprocessing network construction. After a group comparison, components significant differences extracted FCS evaluated. The areas compared between controls. P-values less than 0.05 considered statistically significant. Connection evaluated alphasim, P<0.01. Results component maps altered quantified obtained patients, demonstrating more disconnections mainly bilateral Heschl's gyrus, left cuneus, occipital lobe, amygdala, parahippocampal, fusiform, superior parietal (P<0.01), while compensations may occur frontal-cingulum region, as well among right caudate, thalamus, inferior temporal middle orbital frontal lobe. Conclusion Brain connections, decreased which charging cognition visual function, suggests that might have cognitive decline function loss. However, there be compensatory circle DR.