摘要: The introduction of combination antiretroviral therapy (cART) has significantly decreased the severity HIV-associated neurocognitive disorder (HAND) and increased life expectancy human immunodeficiency virus (HIV) positive population. Nevertheless, patients still show persistent disorders due to associated structural functional brain changes. purpose this chapter is highlight significance neuroimaging techniques biomarkers in understanding pathophysiology related HIV infection HAND. These imaging modalities include volumetric (MRI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), single-photon computed (SPECT), diffusion tensor (DTI), arterial spin labeling (ASL), perfusion MRI. authors predict that with advances at molecular level, it will soon be noninvasive gold standard pathology diagnosis.
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Malcolm J Avison, Avindra Nath, Robin Greene-Avison, Frederick A Schmitt, Rodney A Bales, As'ad Ethisham, Richard N Greenberg, Joseph R Berger, Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia Journal of NeuroVirology. ,vol. 10, pp. 223- 232 ,(2004) , 10.1080/13550280490463532
Lucette A. Cysique, Kirsten Moffat, Danielle M. Moore, Tammy A. Lane, Nicholas W. S. Davies, Andrew Carr, Bruce J. Brew, Caroline Rae, HIV, Vascular and Aging Injuries in the Brain of Clinically Stable HIV-Infected Adults: A 1H MRS Study PLoS ONE. ,vol. 8, pp. e61738- ,(2013) , 10.1371/JOURNAL.PONE.0061738
L Chang, PL Lee, CT Yiannoutsos, T Ernst, CM Marra, T Richards, D Kolson, G Schifitto, JG Jarvik, EN Miller, R Lenkinski, G Gonzalez, Ba A Navia, HIV MRS Consortium, A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age NeuroImage. ,vol. 23, pp. 1336- 1347 ,(2004) , 10.1016/J.NEUROIMAGE.2004.07.067
Rebecca J Melrose, Sule Tinaz, J Mimi Boer Castelo, Maureen G Courtney, Chantal E Stern, Compromised fronto-striatal functioning in HIV: an fMRI investigation of semantic event sequencing. Behavioural Brain Research. ,vol. 188, pp. 337- 347 ,(2008) , 10.1016/J.BBR.2007.11.021
Kerry A. Nichol, Mark W. Schulz, Max R. Bennett, Nitric oxide-mediated death of cultured neonatal retinal ganglion cells: neuroprotective properties of glutamate and chondroitin sulfate proteoglycan Brain Research. ,vol. 697, pp. 1- 16 ,(1995) , 10.1016/0006-8993(95)00695-M
Stefano Aquaro, Luigi Ronga, Michela Pollicita, Andrea Antinori, Alessandro Ranazzi, Carlo Perno, Human immunodeficiency virus infection and acquired immunodeficiency syndrome dementia complex: role of cells of monocyte-macrophage lineage. Journal of NeuroVirology. ,vol. 11, pp. 58- 66 ,(2005) , 10.1080/13550280500513416
E. Schielke, K. Tatsch, H. W. Pfister, C. Trenkwalder, G. Leinsinger, C. M. Kirsch, A. Matuschke, K. M. Einhaupl, Reduced cerebral blood flow in early stages of human immunodeficiency virus infection. JAMA Neurology. ,vol. 47, pp. 1342- 1345 ,(1990) , 10.1001/ARCHNEUR.1990.00530120088015
Brian Ross, Stefan Bluml, Magnetic resonance spectroscopy of the human brain Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 265, pp. 54- 84 ,(2001) , 10.1002/AR.1058
R PANNU, I SINGH, Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms. Neurochemistry International. ,vol. 49, pp. 170- 182 ,(2006) , 10.1016/J.NEUINT.2006.04.010
D. Lopez-Villegas, R. E. Lenkinski, I. Frank, Biochemical changes in the frontal lobe of HIV-infected individuals detected by magnetic resonance spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 9854- 9859 ,(1997) , 10.1073/PNAS.94.18.9854