High cervical lateral spinal cord injury results in long-term ipsilateral hemidiaphragm paralysis.

摘要: Although axon regeneration is limited in the central nervous system, partial lesions of spinal cord induce neuroplasticity processes that can lead to spontaneous functional improvement. To determine whether such compensatory mechanisms occur respiratory we analyzed incidence injury cervical on diaphragm activity adult rats. We show a section lateral area C2 induces complete phrenic nerve inactivation and ipsilateral hemidiaphragm paralysis, whereas medial or dorsolateral sections had only moderate effect activity. In case hemisection, was partially restored after lapse 3 months. No recovery observed, however, even several months hemisection section. Ipsilateral could however be transection contralateral nerve, by activation "crossed phenomenon" (involving previously latent pathways crossing midline). These data suggest system develops important long-term plasticity at level motoneuron innervation. However, they do not themselves allow substantial recovery, underscoring continued need for developing repair strategies. studies also validates use as model evaluate strategies but more sectioning restricted side cord.