An oligopeptide ligand-mediated therapeutic gene nanocomplex for liver cancer-targeted therapy
作者： M. Liu , Z.H. Li , F.J. Xu , L.H. Lai , Q.Q. Wang
DOI: 10.1016/J.BIOMATERIALS.2011.11.082
关键词:
摘要: The epidermal growth factor receptor (EGFR) is over-expressed in a wide variety of epithelial-derived cancer cells. In this study, EGFR-targeted gene carriers were designed to complex the therapeutic acetylcholinesterase (AChE gene), which suppresses cell proliferation via inactivating mitogen-activated protein kinase and PI3K/Akt pathways cells, for treatment EGFR-positive liver cancers. Different amounts target ligand YC21 (an oligopeptide composed 21 amino acid units) coupled with PEI(600)-CD (PC) vectors β-cyclodextrin (β-CD) low-molecular-weight polyethylenimine (PEI, Mw 600) form (termed as YPCs). YPC possessed highly efficient delivery ability YPCs could effectively promote AChE expression. YPC/AChE complexes produced excellent transfection abilities cells vitro vivo.
elsevier.com
sci-hub.se 参考文章(29)
Manfred Ogris, Ernst Wagner, Tumor-targeted gene transfer with DNA polyplexes. Somatic Cell and Molecular Genetics. ,vol. 27, pp. 85- 95 ,(2002) , 10.1023/A:1022988008131
Hong Yao, Samuel S. Ng, Wesley O. Tucker, Yuk-Kai-Tiu Tsang, Kwan Man, Xiao-mei Wang, Billy K.C. Chow, Hsiang-Fu Kung, Gu-Ping Tang, Marie C. Lin, The gene transfection efficiency of a folate-PEI600-cyclodextrin nanopolymer Biomaterials. ,vol. 30, pp. 5793- 5803 ,(2009) , 10.1016/J.BIOMATERIALS.2009.06.051
P.G. Layer, K. Allebrandt, P. Andermann, E. Bodur, R. Boopathy, A.H. Bytyqi, L.E. Paraoanu, On the multifunctionality of cholinesterases. Chemico-Biological Interactions. ,vol. 157, pp. 37- 41 ,(2005) , 10.1016/J.CBI.2005.10.006
Shih-Jiuan Chiu, Naoto T Ueno, Robert J Lee, Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin) conjugated polyethylenimine. Journal of Controlled Release. ,vol. 97, pp. 357- 369 ,(2004) , 10.1016/J.JCONREL.2004.03.019
Hongliang Huang, Hai Yu, Guping Tang, Qingqing Wang, Jun Li, Low molecular weight polyethylenimine cross-linked by 2-hydroxypropyl-γ-cyclodextrin coupled to peptide targeting HER2 as a gene delivery vector Biomaterials. ,vol. 31, pp. 1830- 1838 ,(2010) , 10.1016/J.BIOMATERIALS.2009.11.012
Christophe Le Tourneau, Laura Vidal, Lillian L. Siu, Progress and challenges in the identification of biomarkers for EGFR and VEGFR targeting anticancer agents Drug Resistance Updates. ,vol. 11, pp. 99- 109 ,(2008) , 10.1016/J.DRUP.2008.04.001
Ali Dehshahri, Reza K Oskuee, Wayne T Shier, Arash Hatefi, Mohammad Ramezani, None, Gene transfer efficiency of high primary amine content, hydrophobic, alkyl-oligoamine derivatives of polyethylenimine Biomaterials. ,vol. 30, pp. 4187- 4194 ,(2009) , 10.1016/J.BIOMATERIALS.2009.04.036
G. P. Tang, H. Y. Guo, F. Alexis, X. Wang, S. Zeng, T. M. Lim, J. Ding, Y. Y. Yang, S. Wang, Low molecular weight polyethylenimines linked by β‐cyclodextrin for gene transfer into the nervous system Journal of Gene Medicine. ,vol. 8, pp. 736- 744 ,(2006) , 10.1002/JGM.874
Omid Veiseh, Forrest M. Kievit, Jonathan W. Gunn, Buddy D. Ratner, Miqin Zhang, A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells. Biomaterials. ,vol. 30, pp. 649- 657 ,(2009) , 10.1016/J.BIOMATERIALS.2008.10.003
Peifeng Liu, Zonghai Li, Mingjie Zhu, Ying Sun, Yaogang Li, Hongzhi Wang, Yourong Duan, Preparation of EGFR monoclonal antibody conjugated nanoparticles and targeting to hepatocellular carcinoma Journal of Materials Science: Materials in Medicine. ,vol. 21, pp. 551- 556 ,(2010) , 10.1007/S10856-009-3925-8