Compositions and methods of treating alzheimer's disease

作者: Miklos Jasberenyi , Andrew V. Schally , Norman L. Block

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摘要: Disclosed herein are compositions of GHRH peptide antagonists, and methods to treat Alzheimer's disease other neurodegenerative disorders. Such compounds useful for therapeutics, protecting neuronal cells from cell-death promoting cell viability.

参考文章(13)
Miklos Jaszberenyi, Ferenc G. Rick, Luca Szalontay, Norman L. Block, Marta Zarandi, Ren-Zhi Cai, Andrew V. Schally, Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease Aging (Albany NY). ,vol. 4, pp. 755- 767 ,(2012) , 10.18632/AGING.100504
David T. Hung, Andrew Asher Protter, Methods and combination therapies for treating alzheimer's disease ,(2007)
Jozsef L. Varga, Marta Zarandi, Andrew V. Schally, Ren Zhi Cai, Fluorinated GHRH antagonists ,(2009)
Deepti Nair, Vijay Ramesh, Richard C. Li, Andrew V. Schally, David Gozal, Growth Hormone Releasing Hormone (GHRH) Signaling Modulates Intermittent Hypoxia-Induced Oxidative Stress and Cognitive Deficits In Mouse Journal of Neurochemistry. ,vol. 127, pp. 531- 540 ,(2013) , 10.1111/JNC.12360
Gyula Telegdy, Masaru Tanaka, Andrew V. Schally, Effects of the growth hormone-releasing hormone (GH-RH) antagonist on brain functions in mice Behavioural Brain Research. ,vol. 224, pp. 155- 158 ,(2011) , 10.1016/J.BBR.2011.05.036
Ehud Cohen, Johan F. Paulsson, Pablo Blinder, Tal Burstyn-Cohen, Deguo Du, Gabriela Estepa, Anthony Adame, Hang M. Pham, Martin Holzenberger, Jeffery W. Kelly, Eliezer Masliah, Andrew Dillin, Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice Cell. ,vol. 139, pp. 1157- 1169 ,(2009) , 10.1016/J.CELL.2009.11.014
W. A. Banks, J. E. Morley, S. A. Farr, T. O. Price, N. Ercal, I. Vidaurre, A. V. Schally, Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 22272- 22277 ,(2010) , 10.1073/PNAS.1016369107
Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Ha Giang Thi Nguyen, Fang Yi Su, Er-Yuan Chuang, Hosheng Tu, Pharmaceutical composition of nanoparticles ,(2012)
Agnieszka Siejka, Hanna Lawnicka, Gabriela Melen-Mucha, Ewelina Motylewska, Jan Komorowski, Henryk Stepien, Antineoplastic action of growth hormone-releasing hormone (GHRH) antagonists. Recent Patents on Anti-cancer Drug Discovery. ,vol. 7, pp. 56- 63 ,(2012) , 10.2174/157489212798358010