Growth Hormone Releasing Hormone (GHRH) Signaling Modulates Intermittent Hypoxia-Induced Oxidative Stress and Cognitive Deficits In Mouse

摘要: Intermittent hypoxia (IH) during sleep, such as occurs in obstructive sleep apnea (OSA), leads to degenerative changes the hippocampus, and is associated with spatial learning deficits adult mice. In both patients murine models of OSA, disease suppression growth hormone (GH) secretion, which actively involved growth, development, function central nervous system (CNS). Recent work showed that exogenous GH therapy attenuated neurocognitive elicited by IH rats. Here, we show administration Growth Hormone Releasing (GHRH) agonist JI-34 attenuates IH-induced deficits, anxiety, depression mice along reduction oxidative stress markers MDA 8-hydroxydeoxyguanosine, increases inducible factor-1α DNA binding up-regulation insulin factor-1 erythropoietin expression. contrast, treatment a GHRH antagonist (MIA-602) intermittent did not affect any deleterious effects Thus, administered formulation may provide viable therapeutic intervention protect IH-vulnerable brain regions from OSA-associated dysfunction. Sleep apnea, characterized chronic (IH), substantial cognitive behavioral deficits. (JI-34) reduces stress, HIF-1α nuclear downstream expression IGF1 (EPO) hippocampus cortex, markedly water maze performance exposed sleep.