Intermittent Hypoxia Is Associated with Oxidative Stress and Spatial Learning Deficits in the Rat

摘要: In the adult rat, exposure to intermittent hypoxia (IH), such as occurs in sleep-disordered breathing, is associated with neurobehavioral impairments and increased apoptosis hippocampal CA1 region cortex. We hypothesized that episodic hypoxic-reoxygenation cycles of IH would induce oxidant stress, latter may underlie IH-associated spatial learning retention deficits. Adult male rats were therefore exposed (90-second alternations 10% oxygen 21% oxygen) or room air (RA) for 7 days, received twice-daily injections either 3 mg/kg antioxidant PNU-101033E (PNU) vehicle (V). Rats then trained a standard place-training task water maze. V-IH displayed significant maze, which attenuated by PNU-101033E. Post hoc analyses further revealed had significantly longer latencies pathlengths locate hidden platform than PNU-IH, V-RA, PNU-RA, indicating treatment reduced behavioral IH. addition, markedly increase lipid peroxidation, isoprostane concentrations Collectively, these findings indicate oxidative likely play an important role observed rodent model breathing.