Cardiovascular Autonomic Profile in Women With Premenstrual Syndrome.

摘要: Introduction: The premenstrual syndrome (PMS) is a constellation of somatic and psychogenic symptoms that appear during late luteal (LL) phase the menstrual cycle. Since many could be related to autonomic nervous system, we hypothesized sympathetic system perturbed in PMS. Methods: cardiovascular profile nine women with PMS (30.4±2.5 years) were compared healthy controls (30±2.5 their early follicular (EF) LL phases Plasma norepinephrine (NE) concentrations, power spectral analysis heart rate (HR) systolic blood pressure (BP), baroreflex sensitivity (BRS) assessed recumbency head-up tilt (HUT). Cardiovascular responsiveness α1- β-adrenoreceptor agonists (phenylephrine isoproterenol, respectively) also assessed. Results: In phase, plasma NE concentrations HUT lower than those without (180±30 vs. 320±50 pg/ml; p=0.04 (recumbent), 480±70 940±180 pg/ml: p=0.02 (HUT)). dose phenylephrine required increase BP by 15 mm Hg was significantly greater (202±30 µg versus 138±20 µg; p=0.02). Sympathetic vagal cardiac control indices comparable two groups phases. PMS, value LFSBP EF (0.98±0.2 1.77±0.4 mmHg2, p=0.04). controls, 5.2±0.9 3.1±0.5 p=0.045, this associated significant decrease (BRS). Conclusion: symptoms, circulation not dominant