Importance of inflammation and neurohumoral activation in Takotsubo cardiomyopathy.

摘要: Abstract Background To gain more insight into the involvement of inflammatory response and neurohumoral activation in Takotsubo cardiomyopathy (TTC), we investigated C-reactive protein (CRP), leukocytes, plasma catecholamines levels, iodine 123 meta-iodobenzylguanidine ( I-mIBG) myocardial uptake, perfusion (thallium 201 [ Tl] or technetium [Tc] 99m-tetrofosmin single photon emission computed tomography [SPECT]), metabolism (fluorine 18-fluorodeoxyglucose positron tomography). Methods Results Inflammatory status brain natriuretic peptide (BNP) levels 17 patients with TTC were compared 14 age-matched patients. In TTC, elevated CRP evidenced on admission, reaching a peak following days P I-mIBG SPECT showed reduced activity midventricle apex corresponding to 35% ± 23% total mass, partially reversible at follow-up. An identical pattern was retrieved when assessing glucose metabolism. At rest, no relevant abnormalities could be subacute phase. Conclusion related LVEF impairment extent neurohormonal activation. The hypothesis catecholamine-induced “stunning” is emphasized by evidence activity, metabolism, wall motion kinetic after same temporospatial distribution.