Interactions among gender, age, hypertension and C-reactive protein in coronary vasospasm

摘要: Eur J Clin Invest 2010; 40 (12): 1094–1103 Abstract Background  Coronary vasospasm (CVsp) has been reported to be an inflammatory disease, reflected by elevated high-sensitivity C-reactive protein (hs-CRP). We investigated the interactions among gender, age, hypertension and hs-CRP in patients with CVsp. Materials methods  retrospectively examined 722 Taiwanese or without CVsp during 8-year period. None of had obstructive coronary artery disease. Serum levels were a subset 375 evaluate smoking development CVsp. Results  In women, only highest tertile (> 3 mg L−1) was independently associated CVsp. men, age > 58 years risk demonstrated ≤ 58 years tertile. positively monotonic trend between those age. The odds ratios both women men reduced from 6·01 1·48 6·35–2·69 respectively, if they hypertension. Conclusion  relationship differed women. Our findings that there is non-threshold model threshold provide evidence more smokers (life-style) (induction time) contribute natural history development. negative effect on suggests pathogenesis differs atherosclerosis.