Association between inflammatory markers, hemostatic markers, and traditional risk factors on coronary artery spasm in patients with normal coronary angiography

摘要: Background Coronary artery spasm is an important pathophysiological mechanism in some forms of myocardial ischemic disease. The relationship between inflammatory markers, mean platelet volume (MPV), and coronary unclear. Methods Results During angiography, methylergometrin was injected intravenously to 345 patients with chest pain but without significant disease on angiogram provoke spasm. Based provocation test results, were divided into 2 groups: group (60 patients) nonspasm (285 patients). Inflammatory markers (C-reactive protein, CRP; white blood cells; polymorphonuclear neutrophils, PMN; monocytes, MO; lymphocytes, LY), hemostasis (MPV; count; fibrinogen [FIB]; D-dimers), traditional risk factors (body mass index; hyperlipidemia; triglycerides [TGs]; total, low-density, high-density lipoprotein cholesterol [TC, LDL-C, HDL-C]) measured compared groups. More male experienced (23.56% vs. 11.11%, P = 0.002). CRP, PMN, MO significantly higher the (P < 0.05). There no difference serum levels HDL-C, TG, TC, LY, MPV, FIB Smoking hyperlipidemia more common among spasm; males frequently smokers (58.04% 46.78%, P = 0.041). By multivariate analysis, smoking, associated odds ratios 3.52 (95% CI 1.79–6.90, P = 0.0001), 1.21 1.07–1.46, P = 0.04), 5.35 1.37–21.07, P = 0.01), respectively. Conclusions Inflammation may partake pathogenesis Smoking, PMN count, count appear be clinical for Conversely, does not seem abnormalities thrombogenesis. (J Interven Cardiol 2014;27:29–35)