The distribution of antibacterial agents between plasma and lymph in the dog

摘要: Abstract 1. Plasma, peripheral and thoracic lymph concentrations of penicillin V, phenethicillin, carbenicillin, ampicillin, cloxacillin, G, chloramphenicol sulphadiazine were determined at various time intervals up to 6 h following intramuscular administration 50 mg/kg dogs. 2. Peak plasma the penicillins occurred within half an hour after with peak lymphatic occurring 1·5 3 afterwards. For remaining period test concentration in exceeded corresponding plasma. Sulphadiazine gave equal concentration, but lower while both always than concentrations. 3. After reached, curves for followed same pattern as found plasma, declining exponentially. produced more persistent levels still rising administration. 4. The free whereas less those