Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource

摘要: Hereditary nonpolyposis colorectal cancer (HNPCC) is comprised of the following: family syndrome (CFS), or Lynch II, which shows early-onset proximal colonic predominance and other associated extracolonic adenocarcinomas, particularly endometrial carcinoma; hereditary site-specific colon (HSSCC), I, all same characteristics, except for cancer. Nine families with CFS two HSSCC provided resource that was tested biomarkers (see companion article). All were meticulously evaluated genealogy verification. Biologic specimens obtained during field visits to areas closest geographic proximity families. Cancer education recommendations surveillance/management patients their physicians. Additionally, 40 (about 3000 individuals) either have been ascertained. Syndrome cancers restricted direct-line relatives as opposed nonbloodline relatives, arguing against involvement environmental factors. One documented clinical feature a predilection versus distal in both kindreds. This has important significance it clarifies need instituting effective surveillance earlier detect predominantly cancers.