c-erbB-2 oncoprotein expression in primary human tumors
作者： Amanda McCann , Peter A. Dervan , P. A. Johnston , Desmond N. Carney , William J. Gullick
DOI: 10.1002/1097-0142(19900101)65:1<88::AID-CNCR2820650119>3.0.CO;2-Z
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摘要: Using a specific antiserum (21N) to the c-erbB-2 oncoprotein, total of 405 primary malignant human tumors arising in breast (n = 191), lung 110), colon/rectum 23), bladder 48), prostate and skin 10) were stained immunohistochemically detect those that over-expressed this putative transmembrane receptor. Malignant cells showed intense positivity for oncoprotein 17% carcinomas, 4% colorectal tumors, 2% 1% nonsmall cell carcinomas. No positive staining was evident prostate, skin, or small This study shows over-expression is common cancer but relatively rare other malignancies studied. In addition, can be identified readily routine paraffin-embedded tissue.
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