Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo.
作者： Jun Yokota , Kumao Toyoshima , Takashi Sugimura , Tadashi Yamamoto , Masaaki Terada
DOI: 10.1016/S0140-6736(86)91782-4
关键词:
摘要: There are two genes related to the viral erbB gene in human genome. c-erbB-1 is same as for epithelial-growth-factor (EGF) receptor, and c-erbB-2 encodes a receptor-like protein very similar to, but distinct from, EGF receptor. Hybridisation analysis of DNA from 101 fresh malignant tumours showed that was amplified 5 63 adenocarcinomas none 38 other types tumours, whereas c-erbB-1/EGF-receptor only 1 8 squamous-cell carcinomas. Thus, products may have role evolution adenocarcinomas, does receptor some
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