LungCancerResearchIs TakingOnNewChallenges KnowledgeofTumors'MolecularDiversity IsOpeningNewPathwaystoTreatment

摘要: Lung cancer treatment has evolved in the past decade, leading to remarkable growth number and variety of therapeutic options. Clinicians patients have witnessed a shift from relatively small arsenal mostly chemotherapeutic therapies an expanding array targeted treatments (Table 1) combinations. This change reflects, part, significant refinement molecular categorization lung increasingly successful exploitation diversity tumors. “We clearly can no longer think as monolithic entity,” says Corey Langer, MD, Director Thoracic Oncology Professor Medicine at University Pennsylvania. “With identification actionable or potentially drivers—including not just mutations but translocations other aberrations, most which we weren’t aware even 10 years ago—lung cancers really break down into distinct entities, each should be recognized having separate behaviors.” “As are further subdivided characterized according histology fingerprints,” Dr. Langer adds, “we may see specific beneficial impact on treatment, already begun our with adenocarcinoma, about 25% whom some abnormality that directs their treatment.” As breakthroughs identifying oncogenic drivers