Growth impairment of small-cell cancer by targeting pro-vasopressin with MAG-1 antibody

摘要: AbstractPreviously we demonstrated that human small-cell lung cancer (SCLC) seems to universally express the vasopressin gene, and this leads presence of a cell-surface marker representing entire prohormone precursor. In study show can be targeted with MAG-1, mouse monoclonal antibody against C-terminal moiety on provasopressin. vitro targeting cell lines derived from primary recurrent disease demonstrates attachment surface followed by internalization. vivo 99Tc-labeled Fab fragments MAG-1 shows selective xenografts. treatment tumors classical line, NCI H345, either ~1.65 µCi (~1.65 mg)/kg bw 90 Yttrium-labeled or mg/kg native delivered every second day for 6 days produced similar reductions in growth rate ~50% (p