Clinical evaluation of the neurophysins as tumor markers in small cell lung cancer.

摘要: Small cell carcinoma of the lung (SCCL) is frequently associated with ectopic production peptide hormones, some which produce significant clinical and laboratory abnormalities in patient. The syndromes inappropriate antidiuretic hormone (SIADH) secretion adrenocorticotropic (ACTH) have been well described occur 5%–10% patients suffering from this disease (Kato et al. 1969; Eagan 1974; Lokich 1982). development sensitive radioimmunoassays for hormones such as calcitonin, vasopressin, pro-opiomelanocortin its metabolites (ACTH, lipotropin, B-endorphin), neurophysins, other proteins, carcinoembryonic antigen, neuron-specific enolase, BB isoenzyme creatine kinase, led to detection these substances SCCL. These peptides proteins also detected types cancer, but both frequency quantitative levels are much higher Studies lines SCCL contributed an expansion list detectable culture. Bombesin a large percentage small culture may be functioning autocrine role (Moody 1981; Sorenson However, elevated serum bombesin infrequent (Wood