Protein–protein interactions in transcription: A fertile ground for helix mimetics
作者： Danielle A. Guarracino , Brooke N. Bullock , Paramjit S. Arora
DOI: 10.1002/BIP.21546
关键词:
摘要: Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and leads drug discovery efforts. Selective modulation of has proven to be a daunting task synthetic ligands; however, the last decade seen significant advances inhibitor design, especially helical protein interfaces. This review discusses examples transcriptional complexes targeted by designer helices.
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