Response to letter to editor entitled Methodological remarks concerning the recent meta-analysis on p53 codon 72 polymorphism and colorectal cancer risk

Frank Grünhage, Matthias Jungck, Christoph Lamberti, Christine Berg, Ursula Becker, Hildegard Schulte-Witte, Dominik Plassmann, Nils Rahner, Stefan Aretz, Nicolaus Friedrichs, Reinhard Buettner, Tilman Sauerbruch, Frank Lammert, Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes International Journal of Colorectal Disease. ,vol. 23, pp. 147- 154 ,(2008) , 10.1007/S00384-007-0388-6

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Bente A. Talseth, Cliff Meldrum, Janina Suchy, Grzegroz Kurzawski, Jan Lubinski, Rodney J. Scott, MDM2 SNP309 T>G alone or in combination with the TP53 R72P polymorphism does not appear to influence disease expression and age of diagnosis of colorectal cancer in HNPCC patients. International Journal of Cancer. ,vol. 120, pp. 563- 565 ,(2007) , 10.1002/IJC.22339

Nancy M Wang, CH Tsai, KT Yeh, SJ Chen, JG Chang, None, P53 codon 72Arg polymorphism is not a risk factor for carcinogenesis in the chinese. International Journal of Molecular Medicine. ,vol. 4, pp. 249- 301 ,(1999) , 10.3892/IJMM.4.3.249

Emily L. Webb, Matthew F. Rudd, Gabrielle S. Sellick, Rachid El Galta, Lara Bethke, Wendy Wood, Olivia Fletcher, Steven Penegar, Laura Withey, Mobshra Qureshi, Nichola Johnson, Ian Tomlinson, Richard Gray, Julian Peto, Richard S. Houlston, Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives Human Molecular Genetics. ,vol. 15, pp. 3263- 3271 ,(2006) , 10.1093/HMG/DDL401