Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes
作者： Frank Grünhage , Matthias Jungck , Christoph Lamberti , Christine Berg , Ursula Becker
DOI: 10.1007/S00384-007-0388-6
关键词: Colonoscopy 、 CDH1 、 Cancer 、 Internal medicine 、 Case-control study 、 Allele frequency 、 Medicine 、 Cadherin 、 Cancer research 、 Penetrance 、 Colorectal cancer 、 Gastroenterology
摘要: Introduction About 20% of colorectal cancer (CRC) patients show some kind familiarity, which might be caused by yet unknown combinations low penetrance susceptibility genes. We aimed to identify genetic factors for familial CRC (fCRC) in a unique study design that includes phenotypic extremes as represented fCRC cases and ‘hyper-normal’ controls without history no adenomatous polyps on colonoscopy.
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