Participant‐Reported Health Status Predicts Cardiovascular and All‐Cause Mortality Independent of Established and Nontraditional Biomarkers: Evidence From a Representative US Sample

摘要: Background Participant‐reported health status is a key indicator of cardiovascular health, but its predictive value relative to traditional and nontraditional risk factors unknown. We evaluated whether participant‐reported status, as indexed by self‐rated predicted disease, all‐cause mortality excess 10‐year atherosclerotic disease (ASCVD) scores 5 biomarkers. Methods Results Analyses used prospective observational data from the 1999–2002 National Health Nutrition Examination Surveys among those aged 40 79 years (N=4677). Vital was ascertained through 2011, during which there were 850 deaths, 206 (CVD). regressed CVD on standardized values in survival models, adjusting for age, sex, education, existing chronic race/ethnicity, ASCVD risk, biomarkers (fibrinogen, C‐reactive protein [CRP], triglycerides, albumin, uric acid). In sociodemographically adjusted 1‐SD decrease associated with increased (hazard ratio [HR], 1.92; 95% CI, 1.51–2.45; P <0.001), this hazard remained strong after (HR, 1.79; 1.42–2.26; <0.001). Self‐rated also even adjustment 1.50; 1.35–1.66; <0.001). Conclusions provides prognostic information beyond that captured assessments biomarkers. Consideration combination may facilitate assessment clinical care.