A Nutrigenomics View of Protein Intake

摘要: Proteins are needed for the development and sustainability of life. They molecular machines building blocks in human body that drive or exert most biological functions confer structure function to cell tissue architecture. Dietary proteins provide essential amino acids complement lipid carbohydrate as a major source energy. Therefore, humans must consume sufficient amount quality stay healthy avoid deficiencies. Even with reasonable intake, variability protein consumption can result measurable health consequences specific conditions. This said, dietary delivers more than energy body: pools body, tissue, proteins, peptides, under complex metabolic control, resulting highly dynamic turnover, is, interplay between synthesis degradation. also contain peptide sequences be interpreted bioactive precursors which liberated upon digestion locally (e.g., gut) systemically (i.e., via bloodstream). In this chapter, we will first review holistic readouts intake assessed by omics technologies such gene expression, proteomics, metabolite profiling. Second, look at benefits beyond macronutrient supply describe how generate, analyze, leverage peptides. third part, discuss turnover tackled proteomics tools allow single-protein resolution proteome-wide scale.