Metabolic fate of polyphenols in the human superorganism

摘要: Dietary polyphenols are components of many foods such as tea, fruit, and vegetables associated with several beneficial health effects although, so far, largely based on epidemiological studies. The intact forms complex dietary have limited bioavailability, low circulating levels in plasma. A major part the persists colon, where resident microbiota produce metabolites that can undergo further metabolism upon entering systemic circulation. Unraveling metabolic fate this human superorganism requires joint deployment vitro humanized mouse models intervention trials. Within these systems, variation diversity functionality colonic increasingly be captured by rapidly developing microbiomics metabolomics technologies. Furthermore, is coming to grips large biological superimposed relatively subtle interventions. In particular when deployed conjunction a longitudinal study design, quantitative nutrikinetic signatures obtained. These used define nutritional phenotypes different kinetic characteristics for bioconversion capacity polyphenols. Bottom-up well top-down approaches need pursued link gut microbial and, ultimately, bioactivity This approach will pave way personalization nutrition individuals or populations.