Intestinal Mucosal Immune Response in Experimental Vitamin a Deficiency: Reduction in Helper T Cell Number and Mitogenic Stimulation of Intestinal Intraepithelial Lymphocytes (IEL)
作者： G. Santhi , M. Ramanadham
关键词:
摘要: Abstract Small intestinal intraepithelial lymphocyte (IEL) function has been studied in Vitamin A deficient rats. Weanling Wistar rats were pair-fed a diet for 6–9 weeks period, at which time the (Vit A-) showed significant reduction serum and liver retinol concentration as compared to their control A+) The yield of IEL proliferative response Concanavalin (Con A) significantly reduced Vit A- Phenotypic analysis population using monoclonal antibodies specific rat T lymphocytes its subsets revealed that percentages total helper cell subset decreased However, percentage cells expressing cytotoxic/suppressor phenotype was unaltered These results suggest depressed immune mucosal associated small intestine deficiency.
sci-hub.st 参考文章(26)
M J Brueton, N Lyscom, Intraepithelial, lamina propria and Peyer's patch lymphocytes of the rat small intestine: isolation and characterization in terms of immunoglobulin markers and receptors for monoclonal antibodies. Immunology. ,vol. 45, pp. 775- 783 ,(1982)
Luigi M. De Luca, The Direct Involvement of Vitamin A in Glycosyl Transfer Reactions of Mammalian Membranes Vitamins and Hormones Series. ,vol. 35, pp. 1- 57 ,(1978) , 10.1016/S0083-6729(08)60520-8
Kathleen M. Nauss, David A. Mark, Robert M. Suskind, The Effect of Vitamin A Deficiency on the in Vitro Cellular Immune Response of Rats The Journal of Nutrition. ,vol. 109, pp. 1815- 1823 ,(1979) , 10.1093/JN/109.10.1815
Thomas Goodman, Leo Lefrançois, Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes Nature. ,vol. 333, pp. 855- 858 ,(1988) , 10.1038/333855A0
Marc Bonneville, Charles A. Janeway, Kouichi Ito, Wayne Haser, Isao Ishida, Nobuki Nakanishit, Susumu Tonegawa, Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells Nature. ,vol. 336, pp. 479- 481 ,(1988) , 10.1038/336479A0
L Villa, A Tagliabue, D Boraschi, B Berti, L Nencioni, Natural and antibody-dependent cell-mediated activity against Salmonella typhimurium by peripheral and intestinal lymphoid cells in mice. Journal of Immunology. ,vol. 130, pp. 903- 907 ,(1983)
N Cerf-Bensussan, A K Bhan, D Guy-Grand, C Griscelli, B Lisowska-Grospierre, A monoclonal antibody specific for rat intestinal lymphocytes. Journal of Immunology. ,vol. 136, pp. 76- 82 ,(1986)
A N Naidu, R C Milton, V Reddy, Mild vitamin A deficiency and childhood morbidity--an Indian experience. The American Journal of Clinical Nutrition. ,vol. 46, pp. 827- 829 ,(1987) , 10.1093/AJCN/46.5.827
Susan M. Smith, Nina S. Levy, Colleen E. Hayes, Impaired immunity in vitamin A-deficient mice. Journal of Nutrition. ,vol. 117, pp. 857- 865 ,(1987) , 10.1093/JN/117.5.857
A Sommer, J Katz, I Tarwotjo, Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. The American Journal of Clinical Nutrition. ,vol. 40, pp. 1090- 1095 ,(1984) , 10.1093/AJCN/40.5.1090