Impaired immunity in vitamin A-deficient mice.

摘要: Vitamin A deficiency was produced in mice and used to investigate the role of vitamin immune function. Cellular immunity, as measured by delayed-type hypersensitivity, diminished early before weight appetite changes occurred declined further progressed. Humoral serum immunoglobulin M (IgM) responses a protein antigen (hemocyanin), also declined. The kinetics antibody production were unaffected deficiency. T-cell number remained unchanged, but B-cell macrophage numbers increased A--deficient mice. Surface expression membrane glycoproteins (Thy-1, Lyt-1, Lyt-2, L3T4, IgM, Mac-1) unchanged deficiency, lymphocyte distribution. results suggest that is associated with functional system defect.