Retinoids and Immunity
作者： C. E. Hayes , F. E. Nashold , F. Enrique Gomez , K. A. Hoag
DOI: 10.1007/978-3-642-58483-1_21
关键词:
摘要: Nearly 80years ago at the University of Wisconsin, Mc Collum and Davis (1913) discovered a lipophilic, growth-supportings ubstance, Steenbock et al. (1921) reported that rats ingesting diet devoid this substance, vitamin A, often died respiratory infections. The increased morbidity mortality due to infection was quickly confirmed in A deficient (VAD) rabbits, pigeons, humans (Werkman 1923; Green Mellanby 1928). Mortality from occurred before deficiency signs (xerophthalmia, keratinization) appeared (Boynton Bradford 1931; Coy 1934). These early reports showing causal relationship between predisposition began establish cycle malnutrition (Fig. 1). Greene(1933) documented poor antigen-specific immunoglobulin (Ig) responses VAD animals, Bresse etal. (1942) depletion, completing cycle. challenge then is now elucidate molecular basis for deficiency, immune dysfunction, infection, interrupt with nutritional intervention.
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