Effects of etomidate administration on cerebral collateral flow.

摘要: OBJECTIVE: Augmentation of blood flow to collateral-dependent tissue (CDT) as a result selective vasodilation collateral vessels has been shown occur with various stimuli after middle cerebral artery occlusion. Etomidate, carboxylated imidazole derivative, is nonbarbiturate anesthetic that used clinically both an and neuroprotective agent. The effect etomidate on unknown. purpose our studies was test whether selectively augmented (CBF) CDT during ischemia additional mechanism neuroprotection. METHODS: A left craniotomy performed in each 14 dogs, the animals under halothane anesthesia. branch occluded cannulated distally for determination using shadow technique. CBF vascular pressures were measured calculate resistance. An infusion (0.1 mg/kg body weight/min administered intravenously) started, at 10 40 minutes. Hypotension then induced, again measured. RESULTS: significantly reduced all regions brain, including CDT, when infused. showed 53.7% reduction flow, whereas normal by least 63.4%. During hypotension, 42.7%, cerebrum 22.7%. Vascular resistance increased infusion. CONCLUSION: effects do not seem be through augmentation or global CBF.