An Assessment of the Cerebral Protective Effects of Etomidate in a Model of Incomplete Forebrain Ischemia in the Rat

摘要: The cerebral protective effects of etomidate were evaluated in a model incomplete forebrain ischemia. Fourteen Wistar-Kyoto rats anesthetized with halothane. After preparation, the alloted to either control group (halothane anesthesia, n = 7) or (n 7). In group, immediately before and during period ischemia, animals received sufficient concentration achieve electroencephalogram burst suppression (loading dose, 7.5 mg/kg; infusion, 0.3-0.5 mg/kg/min). Both groups subjected 10-minute ischemic insult accomplished by bilateral carotid artery occlusion simultaneous hypotension (mean arterial pressure, 35 mm Hg). Histological evaluation brain was performed after 4-day recovery period. Injury coronal sections five structures: neocortex, striatum, reticular nucleus thalamus, CA1 CA3 areas hippocampus. location rostral-caudal axis chosen encompass anterior within core territory as well more posterior regions anticipated "watershed" zone between occluded intact circulations. that etomidate, statistically significant (P less than 0.05) reduction severity injury observed area ventral portion hippocampus sections. There an apparent trend toward protection other structures both rostral caudal sections, but these changes not significant.(ABSTRACT TRUNCATED AT 250 WORDS)