Effect of anesthetic induction agents on cardiovascular neuroregulation in dogs.

摘要: The goal of this study was to examine the hypothesis that intravenous anesthetic induction agents alter neuroregulation cardiovascular system. Additional goals were investigate in an animal model devoid other drug effects. Healthy mongrel dogs had arterial catheters inserted and pneumatic occluders positioned around thoracic aorta inferior vena cava. After 10 14 days recovery, neurocirculatory control mechanisms assessed absence anesthesia by recording changes RR interval electrocardiogram response alterations systolic pressure. Systolic pressure manipulated over a range 65 200 mm Hg random occlusion either caval (hypotension) or aortic (hypertension) occluders. animals then given bolus doses thiopental (20 mg/kg), diazepam (2 ketamine (5 etomidate (1.2 mg/kg) on separate order. repeated 3, 10, 20 minutes after drugs given. Regression curves calculated expressing slope relation between at awake each time point administration. responses compared with repeat measures analysis variance. Thiopental significantly decreased for minutes. Diazepam 3 only. Ketamine, like thiopental, Following etomidate, slopes similar control. We conclude diazepam, impair capabilities. effect is only transient, whereas longer, does not affect these reflexes.