CD44: molecular interactions, signaling and functions in the nervous system.

摘要: CD44 is the major surface hyaluronan receptor implicated in intercellular and cell-matrix adhesion, cell migration signalling. It a transmembrane, highly glycosylated protein with several isoforms resulting from alternative gene splicing. The molecule consists of domains serving different functions: N-terminal extracellular domain, stem region, transmembrane domain C-terminal tail. In nervous system, expression occurs both glial neuronal cells. role physiology pathology system not entirely understood, however, there exists evidence suggesting it might be involved axon guidance, cytoplasmic Ca2+ clearance, dendritic arborization, synaptic transmission, epileptogenesis, oligodendrocyte astrocyte differentiation, post-traumatic brain repair tumour development.