CD44 Expression Is Aberrant in Benign Schwann Cell Tumors Possessing Mutations in the Neurofibromatosis Type 2, but not Type 1, Gene

摘要: Atypical expression of CD44 splice variants has been implicated in the progression numerous tumors. This abnormal is presumed to result from gene alterations that cause tumorigenic transformation. Two tumor types have linked specific are schwannomas, which mutations neurofibromatosis (NF) type 2 (NF2) gene, and neurofibromas, characteristically possess NF 1 (NF1) mutations. We examined normal sciatic nerves, schwannomas with confirmed NF2 mutations, neurofibromas malignant peripheral nerve sheath tissue cell lines NF1 patients. Compared express higher total levels additional variants, whereas unaltered. Malignant CD44v6 epitope, not expressed by Schwann cells or other These data indicate altered correlates strictly but suggest might be a marker for transformation cells.