Assessment of pathologic prognostic factors in breast core needle biopsies.

摘要: Background Core needle biopsies (CNB) are being used increasingly as the initial diagnostic procedure in women with breast cancer. Many clinicians interested obtaining much prognostic information possible from these limited specimens. However, accuracy of assessing pathologic factors core biopsy material has not been studied detail. Design We CNB and subsequent excision specimens 79 invasive Slides were reviewed a blinded fashion each was assessed for histologic type, tumor size, grade, lymphatic vessel invasion (LVI), presence an extensive intraductal component (EIC). Results Among cancers, there 58 ductal carcinomas, six lobular 13 carcinomas features two tubular based on examination Histologic type correlated that 64 cases (81%). Although significant correlation between size (r2 = 0.30, P 0.01), T stage underestimated 79% cases. Furthermore, substage 71% T1 lesions. There concordance grade excisions 75% 20 discordant cases, higher than lower seven. all discrepancies within one grade. None 17 cancers LVI specimen showed CNB. 14 EIC specimen, only four (29%) scored having Conclusion can be accurately determined most While majority substantial minority (25%). The ability to determine (pathologic T-stage), LVI, is severely limited.