Histological grading of breast cancer on needle core biopsy: the role of immunohistochemical assessment of proliferation.
作者： T’ng Chang Kwok , Emad A Rakha , Andrew H S Lee , Matthew Grainge , Andrew R Green
DOI: 10.1111/J.1365-2559.2010.03620.X
关键词:
摘要: Kwok T C, Rakha E A, Lee A H S, Grainge M, Green R, Ellis I O & Powe D G (2010) Histopathology57, 212–219 Histological grading of breast cancer on needle core biopsy: the role immunohistochemical assessment proliferation Aims: Histological grade assessed biopsy (NCB) moderately concurs with in surgical excision specimen (SES) (κ-values between 0.35 and 0.65). major cause discrepancy is underestimation mitoses NCB specimen. The aim was to determine best method assessing proliferation NCB. Methods results: Proliferative activity 101 invasive carcinomas SES using mitotic counts routine haematoxylin eosin (H&E) sections markers Mib-1 phosphorylated histone H3 (PPH3). H&E count considered as gold standard. found be underestimated when compared that (P < 0.001), but no significant difference detected regarding (P = 0.13) or PPH3 (P = 0.073). Using receiver–operating characteristic curve, agree standard significantly better than NCB. Conclusions: Immunohistochemical showed concordance (gold standard) NCB. Further refinement cut-offs scoring methods needed.
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